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Feature request: add option to perform gene burden analysis #24

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berntpopp opened this issue Jun 19, 2024 · 3 comments
Open

Feature request: add option to perform gene burden analysis #24

berntpopp opened this issue Jun 19, 2024 · 3 comments
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enhancement New feature or request

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berntpopp commented Jun 19, 2024 •
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This will require subsetting into cohorts and applying a model/ statisical test.
@berntpopp berntpopp self-assigned this Jun 19, 2024
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also see https://github.com/halbritter-lab/stoneformers-multisample-vcf/issues/4

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Relates to #23

Also add counts for cohort sizes (control vs. affected)

@berntpopp berntpopp mentioned this issue Jul 10, 2024
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I think this should be for now a simple test like Fishers exact probands vs. controls with FDR correction of the values just on the merged variant counts.

@berntpopp berntpopp added the enhancement New feature or request label Jul 13, 2024
@berntpopp berntpopp pinned this issue Jul 14, 2024
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