-
Notifications
You must be signed in to change notification settings - Fork 19
/
bXYAWCAIqRE.srt
482 lines (385 loc) · 8.86 KB
/
bXYAWCAIqRE.srt
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
1
00:00:00,500 --> 00:00:00,890
Yes,
2
00:00:01,910 --> 00:00:06,910
you if you can elaborate a bit on,
you mentioned you talked about this
3
00:00:06,910 --> 00:00:11,700
mental process where people do the thing
that's hard but less,
4
00:00:12,270 --> 00:00:15,370
less hard,
but still basically shadow.
5
00:00:15,990 --> 00:00:18,630
That's actually a really productive way
of procrastinating,
6
00:00:18,631 --> 00:00:21,870
although it comes with its own problems
of rationalization,
7
00:00:22,320 --> 00:00:27,320
so reinforces certain circuit.
I'll put it in a way that says that
8
00:00:27,320 --> 00:00:28,730
those can go away,
so you need to bring up the.
9
00:00:29,120 --> 00:00:33,640
The other inhibitory circuits.
Just wondering if you could elaborate.
10
00:00:33,670 --> 00:00:38,670
Well,
I can sure is in the realm of
11
00:00:38,670 --> 00:00:38,670
possibility around their understanding
that.
12
00:00:39,190 --> 00:00:42,140
Well,
I've derived out partly from my study of
13
00:00:42,141 --> 00:00:44,090
addiction and also from my study of
14
00:00:46,520 --> 00:00:48,860
recovery from posttraumatic stress
disorder,
15
00:00:48,920 --> 00:00:53,920
but let's talk about addiction.
So there's a series of actions that
16
00:00:54,690 --> 00:00:59,660
occur before you take your cocaine.
Some of those are local.
17
00:00:59,720 --> 00:01:02,150
They are the things that happened
immediately before and some of those are
18
00:01:02,151 --> 00:01:07,151
distal.
They're farther back in the chain of
19
00:01:07,151 --> 00:01:08,160
events and when you.
When you have a hit of cocaine,
20
00:01:08,180 --> 00:01:11,450
it produces a dopaminergic burst and
that feels really good,
21
00:01:11,451 --> 00:01:15,860
but it also makes the circuits that were
immediately active before that grow.
22
00:01:16,560 --> 00:01:20,330
That's what reinforcement is,
and then the growth is proportionate,
23
00:01:20,870 --> 00:01:25,870
not linearly,
but it's proportionate to how long
24
00:01:25,870 --> 00:01:27,470
before that event occurred.
The closer it is,
25
00:01:27,471 --> 00:01:32,471
the stronger they're going to get,
but even the ones that are somewhat
26
00:01:32,471 --> 00:01:33,230
distal get some reinforcement because
you might say,
27
00:01:33,231 --> 00:01:35,690
well,
what did you do before you,
28
00:01:36,260 --> 00:01:38,630
you found your latest fix?
And the answer is,
29
00:01:38,631 --> 00:01:39,590
well,
how long before?
30
00:01:40,230 --> 00:01:41,210
Well,
the closer,
31
00:01:41,211 --> 00:01:44,540
the more reward.
And so what happens then is that,
32
00:01:44,990 --> 00:01:47,480
so if you take that person out of the
normal environment,
33
00:01:47,481 --> 00:01:50,760
you put them into a treatment center,
they're off.
34
00:01:50,770 --> 00:01:55,770
They're a physical addiction,
which is a weird thing in the case of
35
00:01:55,770 --> 00:01:57,950
cocaine,
but I'm like not that long a week.
36
00:01:57,951 --> 00:02:02,090
I'll do it two weeks for sure.
Even heroin and alcohol for sure,
37
00:02:02,091 --> 00:02:04,760
if you can get them through the seizure
part without dying.
38
00:02:05,210 --> 00:02:07,190
Um,
and so they're done.
39
00:02:07,220 --> 00:02:10,160
They're physiologically dependent
anymore.
40
00:02:10,220 --> 00:02:15,220
But you let that person go.
And the first thing that happens is his
41
00:02:15,220 --> 00:02:18,530
old friend who he's always out doing
drugs with shows up and bang,
42
00:02:18,531 --> 00:02:23,531
he's craving like mad.
And that's because that thing is in an
43
00:02:23,531 --> 00:02:27,131
area is not dead at all and it's
activated by the queue and it's,
44
00:02:28,040 --> 00:02:29,690
it's a circuit.
It's not.
45
00:02:29,720 --> 00:02:33,140
It's a personality.
It only wants one thing at once.
46
00:02:33,140 --> 00:02:38,140
Cocaine,
it's going to suppress any non related
47
00:02:38,140 --> 00:02:39,410
thoughts and it'll use lies.
That's no problem.
48
00:02:39,411 --> 00:02:42,860
Especially if lies have been reinforced,
which they certainly have.
49
00:02:42,980 --> 00:02:47,090
Where are you off to sun,
you know you'll have a live for that and
50
00:02:47,091 --> 00:02:50,990
then 10 minutes later you have your drug
and so that little lie has just grown.
51
00:02:51,350 --> 00:02:54,260
Or maybe you think you've tried to quit.
You think to hell with it.
52
00:02:54,261 --> 00:02:57,860
And every time,
10 minutes before you take your drug,
53
00:02:57,861 --> 00:03:00,700
you think to hell with it.
And you do that a thousand times.
54
00:03:00,880 --> 00:03:03,040
Well believe me that to hell with it,
circuit,
55
00:03:03,400 --> 00:03:08,400
that sucker is strong.
And so it's alive and it's not like it
56
00:03:08,400 --> 00:03:10,170
just disappears.
It can't,
57
00:03:10,450 --> 00:03:12,490
it's you,
it's grown in there.
58
00:03:12,700 --> 00:03:17,700
Now you can build another circuit to
shut it down and you can help decompose
59
00:03:17,700 --> 00:03:20,440
across time by not giving it what it
wants,
60
00:03:20,920 --> 00:03:25,920
but you're going to have to not give it
what it wants in all of the multiple
61
00:03:25,920 --> 00:03:26,830
contexts that you've already associated
with the drug.
62
00:03:27,130 --> 00:03:32,130
Some of you probably smoked and then
tried to quit smoking and what you'll
63
00:03:32,130 --> 00:03:32,800
see is you get a craving when,
well,
64
00:03:32,801 --> 00:03:35,050
when you have a cup of coffee or when
you're finished dinner,
65
00:03:35,051 --> 00:03:40,051
when you're done having a phone call or
when you first get up in the morning or
66
00:03:40,051 --> 00:03:43,200
whenever you've regularly had the drug,
whatever you had the drug in
67
00:03:43,200 --> 00:03:47,641
relationship to even complex things like
ending a conversation will produce a
68
00:03:47,641 --> 00:03:51,951
cute craving and so then that can
extinguish overtime if you punish it by
69
00:03:51,951 --> 00:03:55,290
either punishing it or not letting it
get what it's wants,
70
00:03:55,530 --> 00:04:00,530
but a lot you have to build another
circuit to just shut it down and then
71
00:04:00,530 --> 00:04:02,530
that circuits kind of fragile and stress
can often disrupt it.
72
00:04:03,070 --> 00:04:03,430
So
73
00:04:03,590 --> 00:04:08,470
that can be read about quitting smoking
or things like,
74
00:04:09,360 --> 00:04:09,960
oh sure.
Well,
75
00:04:09,961 --> 00:04:10,560
part of it.
Well,
76
00:04:10,561 --> 00:04:15,561
I begins a whole different thing because
it seems to have a direct physiological
77
00:04:15,561 --> 00:04:15,660
effect,
but you know,
78
00:04:16,200 --> 00:04:17,220
the,
the,
79
00:04:17,280 --> 00:04:22,280
the addiction has a cognitive component.
It's full of thoughts and desires and
80
00:04:22,280 --> 00:04:23,310
wants and you know,
you may have to build,
81
00:04:23,580 --> 00:04:28,580
you have,
may have to rebuild your whole
82
00:04:28,580 --> 00:04:28,740
personality in order to,
to get that thing cornered.
83
00:04:29,280 --> 00:04:34,280
Religious conversion for example,
is in a really effective treatment for
84
00:04:34,280 --> 00:04:37,671
alcoholism.
That's partly why alcoholic alcoholics
85
00:04:37,671 --> 00:04:38,700
anonymous works for the people for whom
it does work,
86
00:04:38,760 --> 00:04:42,330
but religious conversion,
which is total personality conversion is
87
00:04:42,331 --> 00:04:47,331
actually one of the few things that we
know of that's an effective treatment
88
00:04:47,331 --> 00:04:48,030
for alcoholism.
We don't know how to induce it,
89
00:04:48,570 --> 00:04:53,570
but although that's not exactly true
either because I'm in the early work
90
00:04:53,851 --> 00:04:57,520
with Lsd was lsd was quite promising as
a treatment for,
91
00:04:57,680 --> 00:05:02,680
for an alcohol addiction and there's
recent work with silicide button's
92
00:05:02,680 --> 00:05:07,000
showing that if you,
if people have a mystical experience
93
00:05:07,000 --> 00:05:10,701
when you give them Psilocybin,
their success rate and quitting smoking
94
00:05:10,701 --> 00:05:13,851
is about 80 percent,
which is way higher than any
95
00:05:13,851 --> 00:05:14,130
pharmacological intervention for smoking
has ever beat.
96
00:05:14,580 --> 00:05:16,110
So.
Alright.
97
00:05:16,290 --> 00:05:19,440
We should probably call it a day,
so we'll see you in a week.