diff --git a/plugin/trino-base-jdbc/src/main/java/io/trino/plugin/jdbc/DefaultQueryBuilder.java b/plugin/trino-base-jdbc/src/main/java/io/trino/plugin/jdbc/DefaultQueryBuilder.java
index b64ae363a591c..9c5ef6437d011 100644
--- a/plugin/trino-base-jdbc/src/main/java/io/trino/plugin/jdbc/DefaultQueryBuilder.java
+++ b/plugin/trino-base-jdbc/src/main/java/io/trino/plugin/jdbc/DefaultQueryBuilder.java
@@ -289,24 +289,30 @@ public PreparedStatement prepareStatement(
                     .map(jdbcType -> getWriteFunction(client, session, connection, jdbcType, parameter.getType()))
                     .orElseGet(() -> getWriteFunction(client, session, parameter.getType()));
             Class<?> javaType = writeFunction.getJavaType();
-            Object value = parameter.getValue()
-                    // The value must be present, since DefaultQueryBuilder never creates null parameters. Values coming from Domain's ValueSet are non-null, and
-                    // nullable domains are handled explicitly, with SQL syntax.
-                    .orElseThrow(() -> new VerifyException("Value is missing"));
-            if (javaType == boolean.class) {
-                ((BooleanWriteFunction) writeFunction).set(statement, parameterIndex, (boolean) value);
-            }
-            else if (javaType == long.class) {
-                ((LongWriteFunction) writeFunction).set(statement, parameterIndex, (long) value);
-            }
-            else if (javaType == double.class) {
-                ((DoubleWriteFunction) writeFunction).set(statement, parameterIndex, (double) value);
-            }
-            else if (javaType == Slice.class) {
-                ((SliceWriteFunction) writeFunction).set(statement, parameterIndex, (Slice) value);
+
+            if (parameter.getValue().isEmpty()) {
+                writeFunction.setNull(statement, parameterIndex);
             }
             else {
-                ((ObjectWriteFunction) writeFunction).set(statement, parameterIndex, value);
+                Object value = parameter.getValue()
+                        // The value must be present, since DefaultQueryBuilder never creates null parameters. Values coming from Domain's ValueSet are non-null, and
+                        // nullable domains are handled explicitly, with SQL syntax.
+                        .orElseThrow(() -> new VerifyException("Value is missing"));
+                if (javaType == boolean.class) {
+                    ((BooleanWriteFunction) writeFunction).set(statement, parameterIndex, (boolean) value);
+                }
+                else if (javaType == long.class) {
+                    ((LongWriteFunction) writeFunction).set(statement, parameterIndex, (long) value);
+                }
+                else if (javaType == double.class) {
+                    ((DoubleWriteFunction) writeFunction).set(statement, parameterIndex, (double) value);
+                }
+                else if (javaType == Slice.class) {
+                    ((SliceWriteFunction) writeFunction).set(statement, parameterIndex, (Slice) value);
+                }
+                else {
+                    ((ObjectWriteFunction) writeFunction).set(statement, parameterIndex, value);
+                }
             }
         }
 
diff --git a/plugin/trino-base-jdbc/src/test/java/io/trino/plugin/jdbc/BaseJdbcConnectorTest.java b/plugin/trino-base-jdbc/src/test/java/io/trino/plugin/jdbc/BaseJdbcConnectorTest.java
index 1f45eb0e287b0..498dad544a470 100644
--- a/plugin/trino-base-jdbc/src/test/java/io/trino/plugin/jdbc/BaseJdbcConnectorTest.java
+++ b/plugin/trino-base-jdbc/src/test/java/io/trino/plugin/jdbc/BaseJdbcConnectorTest.java
@@ -1868,6 +1868,10 @@ public void testConstantUpdateWithVarcharEqualityPredicates()
             }
             assertUpdate("UPDATE " + table.getName() + " SET col1 = 20 WHERE col2 = 'A'", 1);
             assertQuery("SELECT * FROM " + table.getName(), "VALUES (1, 'a'), (20, 'A')");
+
+            // test update set to null
+            assertUpdate("UPDATE " + table.getName() + " SET col1 = null WHERE col2 = 'A'", 1);
+            assertQuery("SELECT * FROM " + table.getName(), "VALUES (1, 'a'), (null, 'A')");
         }
     }
 
@@ -1883,6 +1887,10 @@ public void testConstantUpdateWithVarcharInequalityPredicates()
 
             assertUpdate("UPDATE " + table.getName() + " SET col1 = 20 WHERE col2 != 'A'", 1);
             assertQuery("SELECT * FROM " + table.getName(), "VALUES (20, 'a'), (2, 'A')");
+
+            // test update set to null
+            assertUpdate("UPDATE " + table.getName() + " SET col1 = null WHERE col2 != 'A'", 1);
+            assertQuery("SELECT * FROM " + table.getName(), "VALUES (null, 'a'), (2, 'A')");
         }
     }
 
@@ -1902,6 +1910,13 @@ public void testConstantUpdateWithVarcharGreaterAndLowerPredicate()
 
             assertUpdate("UPDATE " + table.getName() + " SET col1 = 20 WHERE col2 < 'a'", 1);
             assertQuery("SELECT * FROM " + table.getName(), "VALUES (20, 'a'), (20, 'A')");
+
+            // test update set to null
+            assertUpdate("UPDATE " + table.getName() + " SET col1 = null WHERE col2 > 'A'", 1);
+            assertQuery("SELECT * FROM " + table.getName(), "VALUES (null, 'a'), (2, 'A')");
+
+            assertUpdate("UPDATE " + table.getName() + " SET col1 = null WHERE col2 < 'a'", 1);
+            assertQuery("SELECT * FROM " + table.getName(), "VALUES (null, 'a'), (null, 'A')");
         }
     }