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Implement pathway analysis using decoupler #6

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Tracked by #3
nictru opened this issue Jun 13, 2024 · 3 comments
Open
Tracked by #3

Implement pathway analysis using decoupler #6

nictru opened this issue Jun 13, 2024 · 3 comments
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enhancement New feature or request

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@nictru
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nictru commented Jun 13, 2024

https://decoupler-py.readthedocs.io/en/latest/index.html

@nictru nictru added the enhancement New feature or request label Jun 13, 2024
@nictru nictru added this to the Stable transcriptomics milestone Jun 13, 2024
@gabora
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gabora commented Jun 13, 2024

Hello @nictru,
there is a decoupler nf-core module for bulk analysis (https://nf-co.re/modules/decoupler_decoupler by @Nic-Nic and @vicpaton ) which could probably be a good starting point for this new feature. It handles multiple samples given in a matrix, so if you provide the single cell data as a matrix then it can return the enrichment scores per cells. Reach out to us if we can help,
best
Attila

@nictru
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nictru commented Jun 13, 2024

Thank you very much! Will get back to you :)

@grst
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grst commented Jun 13, 2024

I would even argue that bulk analysis is what you want most of the time, see also this decoupler tutorial:
https://decoupler-py.readthedocs.io/en/latest/notebooks/pseudobulk.html

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